Basic fibroblast growth factor binding is a marker for extracellular neurofibrillary tangles in Alzheimer disease.
نویسندگان
چکیده
منابع مشابه
Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease.
BACKGROUND The relationship between neuropathological lesions and mild, "preclinical," cognitive impairments of Alzheimer disease is poorly understood. Identification of the lesions that are most closely associated with the earliest symptoms of Alzheimer disease is crucial to the understanding of the disease process and the development of treatment strategies to affect its progression. DESIGN...
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The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates intracellular levels of PIP3 and antagonizes the PI3K signaling pathway important for cell survival. The present study determined whether altered distribution of PTEN occurs in Alzheimer's disease (AD) brains. We investigated a possible role for PTEN in postmortem brain tissues from elderly controls and pa...
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Three monoclonal antibodies to neurofilaments (RT97, BF10 and 147), two of which also recognised neurofibrillary tangles (RT97 and BF10), have all been shown to be specific for phosphorylated epitopes. Treatment of histological sections with alkaline phosphatase prior to immunostaining resulted in reduction of axonal neurofilament staining with all three whilst the neurofibrillary tangles stain...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 1991
ISSN: 0022-1554,1551-5044
DOI: 10.1177/39.7.1865106